Four New Highly Oxygenated Eremophilane Sesquiterpenes from an Endophytic Fungus Boeremia exigua Isolated from Fritillaria hupehensis

Journal of Fungi

Zheng-Hui Li¹  Xiao Lv¹  Meng-Xi Wang¹  Hong-Lian Ai¹  Ke Ye¹  Bao-Bao Shi¹  Rong Huang¹ 

[1] School of Pharmaceutical Sciences, South-Central MinZu University, Wuhan 430074, China;

关键词: Boeremia exigua;    Fritillaria hupehensis;    eremophilanes;    boeremialanes;    anti-inflammatory;    NO production inhibition;   

DOI  :  10.3390/jof8050492

来源: DOAJ

【 摘 要 】

Four new eremophilane-type sesquiterpenes, boeremialanes A–D (1–4) were obtained from solid substrate cultures of Boeremia exigua (Didymellaceae), an endophytic fungus isolated from Fritillaria hupehensis (Liliaceae). Boeremialanes A–C (1–3) are highly oxygenated eremophilanes with a benzoate unit attached at the C-13 position and are rarely found in nature. Their structures and absolute configurations were determined by extensive spectroscopic methods, electronic circular dichroism (ECD), and nuclear magnetic resonance (NMR) calculations with DP4+ analysis. Boeremialane D (4) potently inhibited nitric oxide production in lipopolysaccharide-treated RAW264.7 macrophages with an IC₅₀ of 8.62 μM and was more potent than the positive control, pyrrolidinedithiocarbamate (IC₅₀ = 23.1 μM).

【 授权许可】

Unknown