Pharmacogenetic Testing: A Tool for Personalized Drug Therapy Optimization

Pharmaceutics

TatyanaV. Butkova¹  ArthurT. Kopylov¹  KristinaA. Malsagova¹  AlexanderA. Izotov¹  AnnaL. Kaysheva¹  AlexanderA. Stepanov¹  Alexander Tarasov²  DmitryV. Enikeev³  Vagarshak Grigoryan³  NataliaV. Potoldykova³ 

[1] Biobanking Group, Branch of Institute of Biomedical Chemistry “Scientific and Education Center”, 109028 Moscow, Russia;Institute of Linguistics and Intercultural Communication, Sechenov University, 119992 Moscow, Russia;Institute of Urology and Reproductive Health, Sechenov University, 119992 Moscow, Russia;

关键词: pharmacogenetics;    pharmacogenetic test;    personalized medicine;    genetic polymorphism;   

DOI  :  10.3390/pharmaceutics12121240

来源: DOAJ

【 摘 要 】

Pharmacogenomics is a study of how the genome background is associated with drug resistance and how therapy strategy can be modified for a certain person to achieve benefit. The pharmacogenomics (PGx) testing becomes of great opportunity for physicians to make the proper decision regarding each non-trivial patient that does not respond to therapy. Although pharmacogenomics has become of growing interest to the healthcare market during the past five to ten years the exact mechanisms linking the genetic polymorphisms and observable responses to drug therapy are not always clear. Therefore, the success of PGx testing depends on the physician’s ability to understand the obtained results in a standardized way for each particular patient. The review aims to lead the reader through the general conception of PGx and related issues of PGx testing efficiency, personal data security, and health safety at a current clinical level.

【 授权许可】

Unknown