The Paris System for Reporting Urinary Cytology: A Meta-Analysis

Journal of Personalized Medicine

Jordan P. Reynolds¹  Svenja Seide²  Tanja Proctor²  Zoi Kleinaki³  Maria Kleinaki³  Ilias P. Nikas³ 

[1] Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL 32256, USA;Institute of Medical Biometry, University of Heidelberg, 69120 Heidelberg, Germany;School of Medicine, European University Cyprus, Nicosia 2404, Cyprus;

关键词: bladder cancer;    urothelial carcinoma;    urothelial neoplasia;    cytopathology;    urine;    diagnostic accuracy;   

DOI  :  10.3390/jpm12020170

来源: DOAJ

【 摘 要 】

The Paris System (TPS) for Reporting Urinary Cytology is a standardized, evidence-based reporting system, comprising seven diagnostic categories: nondiagnostic, negative for high-grade urothelial carcinoma (NHGUC), atypical urothelial cells (AUC), suspicious for high-grade urothelial carcinoma (SHGUC), HGUC, low-grade urothelial neoplasm (LGUN), and other malignancies. This study aimed to calculate the pooled risk of high-grade malignancy (ROHM) of each category and demonstrate the diagnostic accuracy of urine cytology reported with TPS. Four databases (PubMed, Embase, Scopus, Web of Science) were searched. Specific inclusion and exclusion criteria were applied, while data were extracted and analyzed both qualitatively and quantitatively. The pooled ROHM was 17.70% for the nondiagnostic category (95% CI, 0.0650; 0.3997), 13.04% for the NHGUC (95% CI, 0.0932; 0.1796), 38.65% for the AUC (95% CI, 0.3042; 0.4759), 12.45% for the LGUN (95% CI, 0.0431; 0.3101), 76.89 for the SHGUC (95% CI, 0.7063; 0.8216), and 91.79% for the HGUC and other malignancies (95% CI, 0.8722; 0.9482). A summary ROC curve was created and the Area Under the Curve (AUC) was 0.849, while the pooled sensitivity was 0.669 (95% CI, 0.589; 0.741) and false-positive rate was 0.101 (95% CI, 0.063; 0.158). In addition, the pooled DOR of the included studies was 21.258 (95% CI, 14.336; 31.522). TPS assigns each sample into a diagnostic category linked with a specific ROHM, guiding clinical management.

【 授权许可】

Unknown