Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’InsideTM) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders

Nutrients

Benjamin Moras¹  Camille Monchaux De Oliveira¹  David Gaudout¹  Julien Gabaston¹  Line Pourtau¹  Adeline Vignault¹  Véronique Roux²  Gisèle Pickering²  Nicolas Macian²  Fabien Wauquier³  Line Boutin-Wittrant³  David Vauzour⁴  Nathalie Castanon⁵  Lucile Capuron⁵  Yohann Wittrant⁶  Karène Bertrand⁷  Carole Vaysse⁷  Hélène Abrous⁷ 

[1] Activ’Inside, 33750 Beychac et Caillau, France;CIC INSERM 1405/Plateforme d’Investigation Clinique CHU Gabriel Montpied, 58 Rue Montalembert, 63000 Clermont-Ferrand, France;Clinic’n’Cell SAS, Faculty of Medicine and Pharmacy, TSA 50400, 28 Place Henri Dunant, CEDEX 1, 63001 Clermont-Ferrand, France;Faculty of Medicine and Health Sciences, Biomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK;INRAE, Nutrition and Integrative Neurobiology (NutriNeuro), UMR 1286, 33076 Bordeaux, France;INRAE, UMR 1019, UNH, 63009 Clermont-Ferrand, France;Nutrition-Health & Lipid Biochemistry Department, ITERG, 33610 Canejan, France;

关键词: clinical trial;    depression;    serotonin;    BDNF;    dopamine;    SERT;   

DOI  :  10.3390/nu14071511

来源: DOAJ

【 摘 要 】

Increases in oxidative stress have been reported to play a central role in the vulnerability to depression, and antidepressant drugs may reduce increased oxidative stress in patients. Among the plants exerting anti-inflammatory and anti-oxidant properties, saffron, a spice derived from the flower of Crocus sativus, is also known for its positive effects on depression, potentially through its SSRI-like properties. However, the molecular mechanisms underlying these effects and their health benefits for humans are currently unclear. Using an original ex vivo clinical approach, we demonstrated for the first time that the circulating human metabolites produced following saffron intake (Safr’Inside^TM) protect human neurons from oxidative-stress-induced neurotoxicity by preserving cell viability and increasing BNDF production. In particular, the metabolites significantly stimulated both dopamine and serotonin release. In addition, the saffron’s metabolites were also able to protect serotonergic tone by inhibiting the expression of the serotonin transporter SERT and down-regulating serotonin metabolism. Altogether, these data provide new biochemical insights into the mechanisms underlying the beneficial impact of saffron on neuronal viability and activity in humans, in the context of oxidative stress related to depression.

【 授权许可】

Unknown