High Serum CEA and CYFRA21-1 Levels after a Two-Cycle Adjuvant Chemotherapy for NSCLC: Possible Poor Prognostic Factors

Cancer Biology & Medicine

Xiao-dong Wang¹  Da-qiang Sun²  Yue Bai²  Zhi Li²  Xue-feng Lin³ 

[1] ;Department of Thoracic Surgery, Tianjin Chest Hospital, Tianjin 300051, China;Tianjin Medical College, Tianjin 300222, China;

关键词: non-small-cell lung cancer;    carcinoembryonic antigen;    cytokeratin 19 fragement;    adjuvant chemotherapy;    prognosis;   

DOI  :  10.3969/j.issn.2095-3941.2012.04.009

来源: DOAJ

【 摘 要 】

Objective The aim of this study was to test whether carcinoembryonic antigen (CEA) and cytokeratin 19 fragments (CYFRA21-1) can be used as a prognostic factor for non-small-cell lung cancer (NSCLC) after two cycles of adjuvant chemotherapy in NSCLC patients.
Methods A total of 169 patients underwent at least two cycles of adjuvant chemotherapy. The serum levels of CEA and CYFRA21-1 were recorded after the second cycle of chemotherapy, and the patient follow-up was conducted. Overall survival (OS) and disease-free survival (DFS) were used as the primary endpoint and the secondary endpoint, respectively.
Results The high levels of CEA and CYFRA21-1 after two cycles of adjuvant chemotherapy were poor prognostic factors for OS, with risk ratios (RR) of 2.003 and 1.702, respectively. A high CEA level was a poor prognostic factor (RR 1.152) for DFS. The median survival time (MST) of the high CEA level group was 26 months, whereas that of the normal group was 61 months (P<0.0001). The median DFS time of the high CEA group and the normal group was 34 and 53 months, respectively (P<0.0001). The MST of the high CYFRA21-1 group and the normal group was 43 and 56 months, respectively (P<0.0001).
Conclusions The high serum levels of CEA or CYFRA21-1 after two cycles of adjuvant chemotherapy are poor prognostic factors for NSCLC patients.

【 授权许可】

Unknown