Palladium-Mediated Hydroamination of DNA-Conjugated Aryl Alkenes

Frontiers in Chemistry

关键词: DNA-encoded library;    palladium catalysis;    C-N bond formation;    DNA-conjugated aryl ethylene;    hydroamination;   

DOI  :  10.3389/fchem.2022.851674

来源: DOAJ

【 摘 要 】

C-N bond formation is one of the most commonly used reactions in medicinal chemistry. Herein, we report an efficient Pd-promoted hydroamination reaction between DNA-conjugated aryl alkenes and a wide scope of aliphatic amines. The described reactions are demonstrated in good to excellent conversions to furnish C (sp3)–N bonds on DNA. This DNA-compatible transformation has strong potentials for the application into DNA-encoded library synthesis.

【 授权许可】

Unknown