期刊论文详细信息
Pediatrics and Neonatology
Giant Congenital Melanocytic Nevi in Neonates: Report of Two Cases
Ming-Tzen Liu1  Jen-Chung Chien2  Betau Hwang3  Shu-Jen Chen3  Dau-Ming Niu3  Mao-Shan Wang4  Jiing-Feng Lirng5 
[1] Department of Dermatology, Taipei Veterans General Hospital, Taipei, Taiwan;Department of Pediatrics, Lo-Tung Pohai Hospital, Ilan, Taiwan;Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan;Department of Plastic Surgery, Taipei Veterans General Hospital, Taipei, Taiwan;Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan;
关键词: giant congenital;    melanocytic nevi;    malignant melanoma;    neurocutaneous melanosis;   
DOI  :  10.1016/S1875-9572(10)60012-5
来源: DOAJ
【 摘 要 】

Giant congenital melanocytic nevi are rare, with an estimated incidence of approximately 1 in 20,000 live births. They increase the lifetime risk for malignant melanoma and neurological deficits, including leptomeningeal melanocytosis and epilepsy. Recently, we encountered two patients in whom giant congenital melanocytic nevi were noted at birth. Case 1 presented with the largest nevus spreading across the posterior scalp, neck, chest wall, shoulder and upper back. At the age of 2 months, magnetic resonance imaging (MRI) was performed and no leptomeningeal melanocytosis was found. Case 2 presented with a huge nevus covering most parts of the lower abdomen, lower back, buttocks and bilateral upper thighs. She also had normal MRI findings in the newborn period. At the age of 7 years, leptomeningeal thickening on the surface of the junction between the pons and midbrain was found on brain MRI although she was neurologically asymptomatic. Here, we describe these two cases with congenital melanocytic nevi and review the literature about its clinical manifestations, outcomes, risks for malignant melanoma and neurocutaneous melanosis, and possible surgical interventions.

【 授权许可】

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