Thrombolysis Enhancing by Magnetic Manipulation of Fe3O4 Nanoparticles

Materials

Ming Chang¹  Zhen Lu²  Qian Li³  Xiaojun Liu³ 

[1] Department of Mechanical Engineering, Chung Yuan Christian University, Chung Li 32023, Taiwan;School of Economics and Management, Shanghai University of Electric Power, Shanghai 200090, China;The State Key Laboratory of Digital Manufacturing Equipment and Technology, Huazhong University of Science and Technology, Wuhan 430074, China;

关键词: thrombolysis enhancing;    Fe₃O₄ nanoparticles;    rotating magnetic field;    convective diffusion;    low-dose urokinase;   

DOI  :  10.3390/ma11112313

来源: DOAJ

【 摘 要 】

In this paper, an effective method of accelerating urokinase-administrated thrombolysis through a rotating magnetic field (RMF) of guided magnetic nanoparticles (NPs) in the presence of low-dose urokinase is proposed. The dispersed Fe₃O₄ NPs mixed with urokinase were injected into microfluidic channels occluded by thrombus prepared in vitro. These magnetic NPs aggregated into elongated clusters under a static magnetic field, and were then driven by the RMF. The rotation of Fe₃O₄ aggregates produced a vortex to enhance the diffusion of urokinase to the surface of the thrombus and accelerate its dissolution. A theoretical model based on convective diffusion was constructed to describe the thrombolysis mechanism. The thrombus lysis speed was determined according to the change of the thrombus dissolution length with time in the microfluidic channel. The experimental results showed that the thrombolysis speed with rotating magnetic NPs is significantly increased by nearly two times compared with using the same dose of pure urokinase. This means that the magnetically-controlled NPs approach provides a feasible way to achieve a high thrombolytic rate with low-dose urokinase in use.

【 授权许可】

Unknown