Peritoneal Dialysis Is an Independent Factor Associated to Lower Intima Media Thickness in Dialysis Patients Free From Previous Cardiovascular Disease

Frontiers in Physiology

Miguel Pérez-Fontán¹  Elvira Fernández²  Mercè Borràs²  José M. Valdivielso³  Àngels Betriu³  Marcelino Bermudez-López³  Milica Bozic³  Serafí Cambray³  Maria Crespo-Masip³ 

[1] Nephrology Department, A Coruña Hospital, A Coruña, Spain;Nephrology Department, University Hospital Arnau de Vilanova, Lleida, Spain;Vascular and Renal Translational Research Group, Biomedical Research Institute (IRBLleida), RedinRen RETIC, Instituto de Salud Carlos III, Lleida, Spain;

关键词: intima and media thickness;    dialysis;    cohorts study;    ultrasound;    atherosclerosis;   

DOI  :  10.3389/fphys.2018.01743

来源: DOAJ

【 摘 要 】

Carotid intima media thickness (cIMT) displays prognostic value as a marker of cardiovascular risk in dialysis patients. However, few data are available regarding the impact of dialysis modality on cIMT. The aim of this study is to determine whether the modality of dialysis influences cIMT values. We compared 237 peritoneal dialysis (PD) and 451 hemodialysis (HD) patients without previous cardiovascular disease included in NEFRONA, a prospective, observational and multicenter study. This cross sectional study included the determination of cIMT in 6 carotid territories by arterial ultrasound. cIMT was determined in territories without atheroma plaque and averaged. A second analysis was performed using all territories, giving a truncated cIMT value of 1,5 mm to territories presenting with atheroma plaque. Age and plaque presence at baseline were the clinical variables more closely associated to cIMT in dialysis patients. The evaluation of the impact of the modality of dialysis on cIMT showed that PD patients had lower cIMT than HD patients, both in territories with no plaques and when using truncated cIMT values. No differences were found between right and left sides, neither in cIMT or truncated cIMT values. Lineal multivariate analysis adjusted by several clinical variables showed a statistically significant association of PD with a lower cIMT (slope -0.036; SD 0.010). These results were also confirmed when truncated cIMT values were used. We conclude that the modality of dialysis has an impact on cITM. HD patients have greater global cIMT than PD patients, and PD is and independent factor associated with a lower cIMT.

【 授权许可】

Unknown