Giving short‐term prophylactic antibiotics in patients undergoing open and laparoscopic hepatic resection

Annals of Gastroenterological Surgery

Tokuji Ito¹  Toru Miyazaki¹  Shigekazu Takemura¹  Shoji Kubo¹  Ryosuke Amano¹  Atsushi Ishihara¹  Shogo Tanaka¹  Hiroji Shinkawa¹  Kenjiro Kimura¹  Takayoshi Nishioka¹ 

[1] Department of Hepato‐Biliary‐Pancreatic Surgery Osaka City University Graduate School of Medicine Osaka Japan;

关键词: antibiotics;    antimicrobial;    incidence;    propensity score;    surgical site infection;   

DOI  :  10.1002/ags3.12267

来源: DOAJ

【 摘 要 】

Abstract Aim The 2016 guidelines of the Japan Society for Surgical Infection and the Japan Society of Chemotherapy advocate giving prophylactic antibiotics 1 hour before surgery and until 24 hours after surgery in patients undergoing elective hepatic resection. However, the efficacy of short‐term antimicrobial prophylaxis has not been evaluated according to surgical approach. We evaluated the efficacy of giving prophylactic antibiotics in patients undergoing open or laparoscopic hepatic resection. Methods The study comprised 218 and 185 patients undergoing open and pure laparoscopic hepatic resection, respectively. Incidence rates of postoperative infectious complications were compared between patients who received flomoxef sodium as the prophylactic antibiotic before and until 24 hours after surgery (short‐term group) and those who received flomoxef sodium until 72 hours after surgery (long‐term group) among patients undergoing open or laparoscopic hepatic resection. Propensity score matching analysis was carried out to adjust for confounding factors between the short‐ and long‐term groups. Results There was no significant difference in the postoperative infectious complication incidence between the short‐ and long‐term groups among patients undergoing open (18.9% vs 12.2%; P = 0.36) or laparoscopic (3.3% vs 1.7%; P > 0.99) hepatic resection after propensity score matching. Incidence rate of surgical site infections was comparable between the short‐ and long‐term groups among patients undergoing open (13.5% vs 10.8%; P = 0.80) or laparoscopic (3.3% vs 1.7%; P > 0.99) hepatic resection. Conclusion Giving short‐term prophylactic antibiotics might be sufficient in preventing postoperative infectious complications in patients undergoing open and laparoscopic hepatic resection.

【 授权许可】

Unknown