Ajmaline blocks INa and IKr without eliciting differences between Brugada syndrome patient and control human pluripotent stem cell-derived cardiac clusters

Stem Cell Research

Tyson V. Sharp¹  Pier D. Lambiase²  Elizabeth C. Edwards³  James S. Ware³  Tristan R. McKay⁴  Stephen C. Harmer⁵  Ariel Poliandri⁵  Duncan C. Miller⁵  Andrew Tinker⁵  Muriel Nobles⁵  Leo Dunkel⁵ 

[1] Barts Cancer Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK;Institute of Cardiovascular Science, UCL and Barts Heart Centre, London, UK;National Heart and Lung Institute, NIHR Royal Brompton Cardiovascular BRU, Imperial College London, London, UK;School of Healthcare Science, Manchester Metropolitan University, Manchester, UK;William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK;

关键词: Brugada syndrome;    hiPSC-cardiomyocytes;    Ajmaline;    INa;    IKr;    Activation-recovery interval;   

DOI  :  10.1016/j.scr.2017.11.003

来源: DOAJ

【 授权许可】

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