Prevalence and determinants of diabetes and prediabetes in southwestern Iran: the Khuzestan comprehensive health study (KCHS)

BMC Endocrine Disorders

Aliasghar Valipour¹  Farhad Abolnezhadian²  Ali Akbar Shayesteh³  Bahman Cheraghian⁴  Seyyed Ali Mard⁵  Mohammad Mahdi Mir-Nasseri⁶  Mohammad E. Khamseh⁷  Nahid Hashemi-Madani⁷  Leila Danehchin⁸  Yousef Paridar⁹  Zahra Rahimi^1,10  Sahar Masoudi^1,11  Hossein Poustchi^1,11  Saba Alvand^1,11  Zahra Mohammadi^1,11  Farnaz Hashemi^1,11  Sanam Hariri^1,11  Alireza Khajavi^1,12 

[1]Abadan Faculty of Medical Sciences

[2]Ahvaz Jundishapur University of Medical Sciences

[3]Alimentary Tract Research Center, Clinical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences

[4]Alimentary Tract Research Center, Imam Khomeini Hospital Clinical Research Development Unit, Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences

[5]Alimentary Tract Research Center, Imam Khomeini Hospital Clinical Research Development Unit, School of Medicine, Ahvaz Jundishapur University of Medical Sciences

[6]Digestive Diseases Research Institute, Tehran University of Medical Sciences

[7]Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences

[8]Faculty of Medicine, Behbahan University of Medical Sciences

[9]Faculty of Medicine, Dezful University of Medical Sciences

[10]Hearing Research Center, Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences

[11]Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences

[12]Student Research Committee, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences

关键词: Diabetes;    Prediabetes;    Epidemiology;    Risk-factors;    Low and middle-income countries;    Middle-east;   

DOI  :  10.1186/s12902-021-00790-x

来源: DOAJ

【 摘 要 】

Background The Middle East and North Africa (MENA) is postulated to have the highest increase in the prevalence of diabetes by 2030; however, studies on the epidemiology of diabetes are rather limited across the region, including in Iran. Methods This study was conducted between 2016 and 2018 among Iranian adults aged 20 to 65 years residing in Khuzestan province, southwestern Iran. Diabetes was defined as the fasting blood glucose (FBG) level of 126 mg/dl or higher, and/or taking antidiabetic medications, and/or self-declared diabetes. Prediabetes was defined as FBG 100 to 125 mg/dl. Multinomial logistic regression models were used to examine the association of multiple risk factors that attained significance on the outcome. Results Overall, 30,498 participants were recruited; the mean (±SD) age was 41.6 (±11.9) years. The prevalence of prediabetes and diabetes were 30.8 and 15.3%, respectively. We found a similar prevalence of diabetes in both sexes, although it was higher among illiterates, urban residents, married people, and smokers. Participants aged 50–65 and those with Body Mass Index (BMI) 30 kg/m2 or higher were more likely to be affected by diabetes [RR: 20.5 (18.1,23.3) and 3.2 (3.0,3.6)]. Hypertension [RR: 5.1 (4.7,5.5)], waist circumference (WC) equal or more than 90 cm [RR: 3.6 (3.3,3.9)], and family history [RR: 2.3 (2.2,2.5)] were also significantly associated with diabetes. For prediabetes, the main risk factors were age 50 to 65 years [RR: 2.6 (2.4,2.8)], BMI 30 kg/m2 or higher [RR: 1.9 (1.8,2.0)], hypertension and WC of 90 cm or higher [RR: 1.7 (1.6,1.8)]. The adjusted relative risks for all variables were higher in females than males, with the exception of family history for both conditions and waist circumference for prediabetes. Conclusions Prediabetes and diabetes are prevalent in southwestern Iran. The major determinants are older age, obesity, and the presence of hypertension. Further interventions are required to escalate diabetes prevention and diagnosis in high-risk areas across Iran.

【 授权许可】

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