Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach

Pharmaceutics

Koen Robeyns¹  Laurent Collard¹  Camila Caro Garrido¹  Tom Leyssens¹  Xavier Buol¹  Johan Wouters²  Nikolay Tumanov² 

[1] Institute of Condensed Matter and Nanosciences, UCLouvain, 1 Place Louis Pasteur, B-1348 Louvain-la-Neuve, Belgium;Namur Research Institute for Life Sciences (Narilis), Chemistry department, UNamur, 61 rue de Bruxelles, B-5000 Namur, Belgium;

关键词: nefiracetam;    solid state;    cocrystals;    solubility;    dissolution rate;    stability;   

DOI  :  10.3390/pharmaceutics12070653

来源: DOAJ

【 摘 要 】

In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully structurally and physically characterized and the solubility, dissolution rate, and stability were compared to that of the initial Active Pharmaceutical Ingredient (API).

【 授权许可】

Unknown