The association of patient age with postoperative morbidity and mortality following resection of intracranial tumors

Brain and Spine

Asgeir S. Jakola¹  Johannes Kerschbaumer¹  Mirjam Renovanz¹  Julia Velz²  Martin N. Stienen³  Florian Ringel⁴  Anna M. Zeitlberger⁵  Morgan Broggi⁵  Marike L.D. Broekman⁶  Yang Yang⁷  Victor E. Staartjes⁷  Marian C. Neidert⁷  Jiri Bartek, Jr.⁸  Flavio Vasella⁸  Julius M. Kernbach⁹  Luca Regli⁹  Niklaus Krayenbühl⁹  Paolo Ferroli⁹  Georg Neuloh⁹  Oliver Bozinov^1,10  Konstantin R. Brawanski^1,11  Darius Kalasauskas^1,11  Christian F. Freyschlag^1,11  Hans Christoph Bock^1,12  Abdelhalim Hussein^1,12  Alexandra Sachkova^1,12  Veit Rohde^1,13  Cynthia M.C. Lemmens^1,14  Costanza Maria Zattra^1,15  Alexander Fletcher-Sandersjöö^1,15  Petter Förander^1,15  Claudine O. Nogarede^1,16  Bawarjan Schatlo^1,17  Kristin Sjåvik^1,17  Ole Solheim^1,17 

[1] Department of Clinical Neuroscience and Medicine, Karolinska Institutet, Stockholm, Sweden;Department of Neurology, Public Health and Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy;Department of Neurosurgery, Leiden University Medical Center, Leiden, the Netherlands;Department of Neurosurgery, Rigshospitalet, Copenhagen, Denmark;Department of Neurosurgery, University Hospital Zurich and Clinical Neuroscience Center, University of Zurich, Zurich, Switzerland;Institute of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg, Sweden;Department of Neurosurgery, Cantonal Hospital of St. Gallen, St. Gallen, Switzerland;Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy;Department of Neurosurgery, Georg August University, University Medical Center, Göttingen, Germany;Department of Neurosurgery, Haaglanden Medical Center, The Hague, the Netherlands;Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden;Department of Neurosurgery, Medical University of Innsbruck, Innsbruck, Austria;Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden;Department of Neurosurgery, St. Olavs University Hospital, Trondheim, Norway;Department of Neurosurgery, University Hospital Zurich and Clinical Neuroscience Center, University of Zurich, Zurich, Switzerland;Department of Neurosurgery, University Hospital of North Norway, Tromsö, Norway;Department of Neurosurgery, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany;

关键词: Intracranial tumor;    Functional status;    Outcome;    Age;    Risk factor;    KPS;   

DOI  :  

来源: DOAJ

【 摘 要 】

Introduction: The postoperative functional status of patients with intracranial tumors is influenced by patient-specific factors, including age. Research question: This study aimed to elucidate the association between age and postoperative morbidity or mortality following the resection of brain tumors. Material and methods: A multicenter database was retrospectively reviewed. Functional status was assessed before and 3–6 months after tumor resection by the Karnofsky Performance Scale (KPS). Uni- and multivariable linear regression were used to estimate the association of age with postoperative change in KPS. Logistic regression models for a ≥10-point decline in KPS or mortality were built for patients ≥75 years. Results: The total sample of 4864 patients had a mean age of 56.4 ​± ​14.4 years. The mean change in pre-to postoperative KPS was −1.43. For each 1-year increase in patient age, the adjusted change in postoperative KPS was −0.11 (95% CI -0.14 - - 0.07). In multivariable analysis, patients ≥75 years had an odds ratio of 1.51 to experience postoperative functional decline (95%CI 1.21–1.88) and an odds ratio of 2.04 to die (95%CI 1.33–3.13), compared to younger patients. Discussion: Patients with intracranial tumors treated surgically showed a minor decline in their postoperative functional status. Age was associated with this decline in function, but only to a small extent. Conclusion: Patients ≥75 years were more likely to experience a clinically meaningful decline in function and about two times as likely to die within the first 6 months after surgery, compared to younger patients.

【 授权许可】

Unknown