SMILE Platform: An Innovative Microfluidic Approach for On-Chip Sample Manipulation and Analysis in Oral Cancer Diagnosis

Micromachines

Elisabetta Primiceri¹  Francesco Ferrara¹  Maria Serena Chiriacò¹  Sofia Zoupanou²  Annalisa Volpe³  Antonio Ancona³  Caterina Gaudiuso³ 

[1] CNR NANOTEC—Institute of Nanotechnology, Via per Monteroni, 73100 Lecce, Italy;Department of Mathematics & Physics E. de Giorgi, University of Salento, Via Arnesano, 73100 Lecce, Italy;Physics Department, University of Bari “Aldo Moro”, Via Orabona 4, 70126 Bari, Italy;

关键词: oral cancer;    circulating tumor cells;    micromixers;    3D microfluidics;    biodetection;    plastic microfluidics;   

DOI  :  10.3390/mi12080885

来源: DOAJ

【 摘 要 】

Oral cancer belongs to the group of head and neck cancers, and, despite its large diffusion, it suffers from low consideration in terms of prevention and early diagnosis. The main objective of the SMILE platform is the development of a low-cost device for oral cancer early screening with features of high sensitivity, specificity, and ease of use, with the aim of reaching a large audience of possible users and realizing real prevention of the disease. To achieve this goal, we realized two microfluidic devices exploiting low-cost materials and processes. They can be used in combination or alone to obtain on-chip sample preparation and/or detection of circulating tumor cells, selected as biomarkers of oral cancer. The realized devices are completely transparent with plug-and-play features, obtained thanks to a highly customized architecture which enables users to easily use them, with potential for a common use among physicians or dentists with minimal training.

【 授权许可】

Unknown