A circuit motif in the zebrafish hindbrain for a two alternative behavioral choice to turn left or right

eLife

Francesca Minale¹  Minoru Koyama²  Chris B Schaffer³  Joseph R Fetcho³  Nozomi Nishimura³  Jennifer Shum³ 

[1] Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, United States;Department of Neurobiology and Behavior, Cornell University, Ithaca, United States;Meinig School of Biomedical Engineering, Cornell University, Ithaca, United States;

关键词: motor control;    escape;    inhibitory interneurons;   

DOI  :  10.7554/eLife.16808

来源: DOAJ

【 摘 要 】

Animals collect sensory information from the world and make adaptive choices about how to respond to it. Here, we reveal a network motif in the brain for one of the most fundamental behavioral choices made by bilaterally symmetric animals: whether to respond to a sensory stimulus by moving to the left or to the right. We define network connectivity in the hindbrain important for the lateralized escape behavior of zebrafish and then test the role of neurons by using laser ablations and behavioral studies. Key inhibitory neurons in the circuit lie in a column of morphologically similar cells that is one of a series of such columns that form a developmental and functional ground plan for building hindbrain networks. Repetition within the columns of the network motif we defined may therefore lie at the foundation of other lateralized behavioral choices.

【 授权许可】

Unknown