Preparation and Preliminary Biological Evaluation of Novel 99mTc-Labelled Thymidine Analogs as Tumor Imaging Agents

Molecules

关键词: thymidine derivative;    <;    sup>;    99m<;    /sup>;    Tc-labelled;    biodistribution;    tumor imaging;   

DOI  :  10.3390/molecules17078518

来源: DOAJ

【 摘 要 】

Two kinds of novel thymidine derivatives, N-thymidine-yl-N′-methyl-N′-{N′′-[2-sulfanyl-(ethylamino)acetyl]-2-aminoethylsulfanyl-1-hexanamide}-ethanediamine (TMHEA) and N-thymidine-yl-N′-methyl-N′-{N′′-[2-sulfanyl-(ethylamino)acetyl]-2-aminoethylsulfanyl-1-hexanamide}-hexanediamine (TMHHA) were prepared and successfully labeled with ^99mTc in high labeling yields. The in vitro stability and in vivo biodistribution of ^99mTc-TMHEA and ^99mTc-TMHHA were investigated and compared. The biodistribution studies indicate that the radiotracer ^99mTc-TMHEA displays selective tumor uptake, suggesting it is a potential tumor imaging agent.

【 授权许可】

Unknown