Maternal serum eye drops to treat bilateral neurotrophic keratopathy in congenital corneal anesthesia: Case report and literature review

American Journal of Ophthalmology Case Reports

Andrea Lucisano¹  Cristina Malaventura²  Alessandra Mancini³  Gianfranco Scuteri⁴  Marco Pellegrini⁵  Massimo Busin⁵  Vincenzo Scorcia⁵  Giuseppe Giannaccare⁵ 

[1] Corresponding author. University of Magna Græcia, Viale Europa, 88100, Germaneto, Catanzaro, Italy.;Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy;Istituto Internazionale per la Ricerca e Formazione in Oftalmologia (IRFO), Forlì, Italy;Department of Ophthalmology, Ospedali Privati Forlì“Villa Igea”, Forlì, Italy;Department of Ophthalmology, University Magna Græcia of Catanzaro, Catanzaro, Italy;

关键词: Congenital corneal anesthesia;    Neurotrophic keratopathy;    Serum eye drops;    Blood-derived eye drops;   

DOI  :  

来源: DOAJ

【 摘 要 】

Purpose: To report the feasibility and the successful outcomes of a pediatric neurotrophic keratopathy (NK) owing to congenital corneal anesthesia (CCA) treated with allogeneic serum eye drops obtained from the mother as the only therapy. Observations: A 18-month-old girl with generalized pain insensitivity presented with a large epithelial defect in the right eye (RE) and superficial punctate keratopathy (SPK) in the left eye (LE). Corneal sensitivity was completely absent in both eyes (BE). Peripheral serum eye drops obtained from the mother was prescribed and administered every 2 hours in BE. Two weeks after the beginning of treatment, compete healing of the epithelial defect in the RE was obtained, while the severity of the SPK in the LE markedly improved; in parallel, conjunctival hyperemia disappeared in BE. The treatment was continued over the course of 3 months with good tolerability and neither signs of recurrence of the epithelial defect nor other complications were noted. Conclusions and Importance: Allogeneic serum eye drops obtained from the mother are effective in treating pediatric NK owing to CCA. This treatment may represent a readily available and inexpensive option when topical nerve growth factor is unavailable or corneal neurotization is not feasible.

【 授权许可】

Unknown