Neuromodulation via the Cerebrospinal Fluid: Insights from Recent in Vitro Studies

Frontiers in Neural Circuits

Andreas Bjorefeldt³  Eric Hanse⁴  Sebastian Illes⁴  Henrik Zetterberg⁶ 

[1] Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden;Department of Molecular Neuroscience, UCL Institute of Neurology, University College London, London, United Kingdom;Department of Neuroscience, Brown University, Providence, RI, United States;Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden;Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden;United Kingdom Dementia Research Institute, University College London, London, United Kingdom;

关键词: cerebrospinal fluid;    neuromodulation;    neural circuit;   

DOI  :  10.3389/fncir.2018.00005

来源: DOAJ

【 摘 要 】

The cerebrospinal fluid (CSF) occupies the brain’s ventricles and subarachnoid space and, together with the interstitial fluid (ISF), forms a continuous fluidic network that bathes all cells of the central nervous system (CNS). As such, the CSF is well positioned to actively distribute neuromodulators to neural circuits in vivo via volume transmission. Recent in vitro experimental work in brain slices and neuronal cultures has shown that human CSF indeed contains neuromodulators that strongly influence neuronal activity. Here we briefly summarize these new findings and discuss their potential relevance to neural circuits in health and disease.

【 授权许可】

Unknown