Super refractory status epilepticus secondary to anti-GAD antibody encephalitis successfully treated with aggressive immunotherapy

Epilepsy & Behavior Reports

Fatima Jaafar¹  Laith Haddad¹  Nadia Koleilat¹  Rolla Shbarou¹  Rana Sharara-Chami² 

[1] Division of Child Neurology, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon;Division of Pediatric Critical Care, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon;

关键词: Autoimmune encephalitis;    Glutamic acid decarboxylase antibodies;    Limbic encephalitis;    Status epilepticus;    Tocilizumab;   

DOI  :  

来源: DOAJ

【 摘 要 】

Antibodies against glutamic acid decarboxylase are reported in association with a number of neurological conditions including limbic encephalitis. We report a case of anti-GAD-antibody associated encephalitis presenting with super-refractory status epilepticus. We describe the clinical course, management, and the outcome. In addition, we review the presentation and outcomes of reported cases of anti-GAD encephalitis. Similar to the reported cases of anti-GAD encephalitis, our case was refractory to treatment with conventional antiseizure medication. Treatment with intravenous immune globulin (IVIG), high dose corticosteroids, and plasmapheresis had partial response, but escalation of treatment to the use of tocilizumab was associated with significant clinical improvement.

【 授权许可】

Unknown