Elimination of Cas9-dependent off-targeting of adenine base editor by using TALE to separately guide deaminase to target sites

Cell Discovery

Ting Lan¹  Yang Liu¹  Liangxue Lai¹  Quanjun Zhang¹  Shuwen Zheng²  Lingyin Cheng²  Qingjian Zou²  Xiaoqing Zhou²  Chuan Li²  Yuling Zheng²  Min Chen²  Yang Yang³  Jizeng Zhou³  Shu Wei⁴ 

[1] CAS Key Laboratory of Regenerative Biology, Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Joint Research Laboratory on Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences;Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, School of Biotechnology and Health Sciences, Wuyi University;School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology;State Key Laboratory of Conservation and Utilization of Bio-Resources in Yunnan and Center for Life Science, School of Life Sciences, Yunnan University;

DOI  :  10.1038/s41421-022-00384-4

来源: DOAJ

【 授权许可】

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