期刊论文详细信息
Brain Stimulation | |
61% of unmedicated treatment resistant depression patients who did not respond to acute TMS treatment responded after four weeks of twice weekly deep TMS in the Brainsway pivotal trial | |
Aron Tendler1  Abraham Zangen2  Mark S. George3  Linda L. Carpenter4  Agustin G. Yip5  Yiftach Roth6  | |
[1]Corresponding author. Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, 345Blackstone Boulevard, Providence, RI, United States. | |
[2]Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, United States | |
[3]Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, RI, United States | |
[4]Brainsway Ltd, Jerusalem, Israel | |
[5]Butler Hospital, Providence, RI, United States | |
[6]Ralph H Johnson VA Medical Center, Charleston, SC, United States | |
关键词: Clinical research; Transcranial magnetic stimulation; Treatment-resistant depression; Randomized clinical trial; | |
DOI : | |
来源: DOAJ |
【 摘 要 】
Background: An acute course of dTMS typically involves treatments delivered 5 days a week, for 4 weeks. Should more treatments be given if the patient has not responded? Data are needed to inform decisions about the best next steps for acute non-responders. Objective: To characterize response among acute-phase non-responders in a randomized controlled trial of deep repetitive transcranial magnetic stimulation (dTMS) monotherapy for medication-resistant depression. Methods: Summary statistics and Kaplan-Meier curves were used to characterize outcomes of 33 medication-free Brainsway™ dTMS non-responders to double blind but active treatment at the end of 4 weeks (20 sessions), who then continued double blind but active twice–weekly treatment for up to 12 additional weeks. Results: 24 participants (72.7%) achieved responder status during at least one rating with dTMS continuation -- 20 (60.6%) within four weeks, with 13 (39.4%) consistently meeting response criteria for the duration of the study. 20 (63.6%) achieved remission status at some point during treatment continuation. Conclusions: A significant proportion of acute course non-responders to dTMS treatment eventually respond with continued treatment. Continuing TMS treatment beyond the acute course for non-responders may result in eventual response in over half of these individuals.【 授权许可】
Unknown