Gut Microbial Antigenic Mimicry in Autoimmunity

Frontiers in Immunology

Pere Santamaria¹  Nahir Garabatos² 

[1] Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada;Institut D’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain;Julia McFarlane Diabetes Research Centre (JMDRC), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada;

关键词: gut microbiota;    dysbiosis;    autoreactive T-cell responses;    autoimmune disease;    molecular mimicry;    gut microbial metabolites;   

DOI  :  10.3389/fimmu.2022.873607

来源: DOAJ

【 摘 要 】

The gut microbiota plays a major role in the developmental biology and homeostasis of cells belonging to the adaptive and innate arms of the immune system. Alterations in its composition, which are known to be regulated by both genetic and environmental factors, can either promote or suppress the pathogenic processes underlying the development of various autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, systemic lupus erythematosus, type 1 diabetes and rheumatoid arthritis, to just name a few. Cross-recognition of gut microbial antigens by autoreactive T cells as well as gut microbe-driven alterations in the activation and homeostasis of effector and regulatory T cells have been implicated in this process. Here, we summarize our current understanding of the positive and negative associations between alterations in the composition of the gut microbiota and the development of various autoimmune disorders, with a special emphasis on antigenic mimicry.

【 授权许可】

Unknown