Sclerin, a New Cytotoxic Cyclononapeptide from Annona scleroderma

Molecules

Francisco Cen-Pacheco¹  Dalia Santos-Luna¹  Gerardo Valerio-Alfaro²  JoséJavier Fernández³ 

[1] Faculty of Bioanalysis, Veracruz University, Iturbide s/n, Veracruz 91700, Mexico;Food Research and Development Unit, Tecnológico Nacional de México-I T Veracruz-UNIDA. M.A. de Quevedo 2779, Col. Formando Hogar Veracruz Ver. C.P., Mexico 91860, Mexico;Institute of Bio-Organic Chemistry Antonio González, Department of Organic Chemistry, University of La Laguna, Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Spain;

关键词: cyclopeptide;    cyclononapeptide;    cytotoxic compound;    Annona;   

DOI  :  10.3390/molecules24030554

来源: DOAJ

【 摘 要 】

A new cytotoxic cyclononapeptide, sclerin, cyclo(⁻Dab¹⁻Ser²⁻Tyr³⁻Gly⁴⁻Thr⁵⁻Val⁶⁻Ala⁷⁻ Ile⁸⁻Pro⁹⁻) (1), was isolated from the methanol extract of the seeds of Annona scleroderma, together with the known metabolite, cyclosenegalin A, cyclo(⁻Pro¹⁻Gly²⁻Leu³⁻Ser⁴⁻Ala⁵⁻Val⁶⁻Thr⁷⁻) (2). The planar structures for the two compounds were established by comprehensive analysis of NMR and ESI-HRMS data, and the absolute stereochemistry was stablished by Marfey’s method. Compound 1 showed moderate cytotoxic activity against the human prostate carcinoma cell line DU-145 at µM concentration.

【 授权许可】

Unknown