Toxic Effects of Endocrine Disruptor Exposure on Collagen-Induced Arthritis

Biomolecules

Marika Cordaro¹  Rosalba Siracusa²  Livia Interdonato²  Alessio Filippo Peritore²  Davide Di Paola²  Salvatore Cuzzocrea²  Ramona D’Amico²  Daniela Impellizzeri²  Tiziana Genovese²  Roberta Fusco³  Rosanna Di Paola⁴  Rosalia Crupi⁴  Enrico Gugliandolo⁴ 

[1] Department of Biomedical, Dental and Morphological and Functional Imaging, University of Messina, 98125 Messina, Italy;Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy;Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy;Department of Veterinary Science, University of Messina, 98168 Messina, Italy;

关键词: endocrine disruptors;    arthritis;    inflammation;    oxidative stress;   

DOI  :  10.3390/biom12040564

来源: DOAJ

【 摘 要 】

Endocrine disruptors (EDs) are chemical substances capable of affecting endocrine system functioning and interfering with organ morphogenesis and physiological functions. The development and regeneration of bone tissues have a complex hormonal regulation, and therefore, bone tissue cells can be considered potential targets for endocrine disruptors. In that regard, the aim of this research was to investigate the impact of ED exposure on the inflammatory response and oxidative stress in an experimental model of collagen-induced arthritis (CIA). Arthritis was induced by an emulsion of type II collagen (CII) and complete Freund’s adjuvant, which was administered intradermally on days 0 and 21. Mice from day 21 to day 35 received the following EDs by oral gavage: cypermethrin (CP), diethyl phthalate (DEP), vinclozolin (VCZ), 17α-ethinylestradiol (EE), perfluorooctanesulfonic acid (PFOS) and atrazine (ATR). ED exposure caused worsening of clinical signs (erythema and edema in the hind paws), histological and radiographic changes, as well as behavioral deficits, induced by CII injections. Furthermore, ED exposure significantly increased the degree of inflammation and oxidative damage induced by arthritis; this upregulation was more evident after exposure to ATR than to other EDs. The results from our study suggest that exposure to EDs may play a deleterious role in the progression of RA; therefore, exposure to EDs should be limited.

【 授权许可】

Unknown