High Fat High Sucrose Diet Modifies Uterine Contractility and Cervical Resistance in Pregnant Rats: The Roles of Sex Hormones, Adipokines and Cytokines

Life

Eszter Ducza¹  Adrienn Csányi¹  Anita Sztojkov-Ivanov¹  Éva Szökő²  Tamás Tábi²  Fruzsina Bagaméry²  Mohsen Mirdamadi³  Tamara Barna³  Róbert Gáspár³  Judit Hajagos-Tóth³  Anna Kothencz³  Orsolya Kovács³  Lilla Siska-Szabó³  Annamária Schaffer³  Reza Samavati³  Kálmán Ferenc Szűcs³  Sandor G. Vari⁴ 

[1] Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, 6720 Szeged, Hungary;Department of Pharmacodynamics, Semmelweis University, 1089 Budapest, Hungary;Department of Pharmacology and Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, 6720 Szeged, Hungary;International Research and Innovation in Medicine Program, Cedars–Sinai Medical Center, Los Angeles, CA 90048, USA;

关键词: obesity;    pregnancy;    rat;    adipokines;    cytokines;    sex hormones;   

DOI  :  10.3390/life12060794

来源: DOAJ

【 摘 要 】

Background: In obesity, the adipose tissue becomes a very significant endocrine organ producing different factors called adipokines, such as leptin, adiponectin and kisspeptin; however, no data are available about their actions on uterine contraction in obese pregnant rats. Our aim was to study the impact of obesity on pregnant uterine contraction in a rat model. Methods: Obesity was induced by the consumption of a high fat high sucrose diet (HFHSD) for 9 weeks, including pregnancy. Glucose tolerance, sex hormone, cytokine and adipokine levels were measured. Uterine contractions and cervical resistance, as well as their responses to adipokines, were tested along with the expressions of their uterine receptors. Results: HFHSD increased body weight, and altered glucose tolerance and fat composition. The uterine leptin and kisspeptin pathway affect increased. The levels of proinflammatory cytokines were reduced, while the plasma level of progesterone was increased, resulting in weaker uterine contractions, and improving the uterine relaxing effects of adipokines. HFHSD reduced cervical resistance, but the core effect of adipokines is difficult to determine. Conclusions: Obesity in pregnant rats reduces uterine contractility and cytokine-induced inflammatory processes, and therefore obese pregnant rat methods are partially applicable for modelling human processes.

【 授权许可】

Unknown