Hypertonic Solution in Severe COVID-19 Patient: A Potential Adjuvant Therapy

Frontiers in Medicine

Alexandre Dermargos¹  Leandro Borges¹  Eleine Weimann¹  Elaine Hatanaka¹  Matheus Gennari-Felipe¹  Tania Cristina Pithon-Curi¹  Rui Curi² 

[1] Instituto de Ciências da Atividade Física e Esportes, Universidade Cruzeiro do Sul, São Paulo, Brazil;Seção de Produção de Imunobiológicos, Centro Bioindustrial, Instituto Butantan, São Paulo, Brazil;

关键词: coronavirus;    leukocytes;    neutrophils;    immune system;    NETs;    NETosis;   

DOI  :  10.3389/fmed.2022.917008

来源: DOAJ

【 摘 要 】

Coronavirus disease 2019 (COVID-19) features hyper-inflammation, cytokine storm, neutrophil function changes, and sodium chloride (NaCl) homeostasis disruption, while the treatment with NaCl hypertonic solutions (HS) controls electrolytic body homeostasis and cell functions. HS treatment is a simple, popular, economic, and feasible therapy to regulate leukocyte function with a robust anti-inflammatory effect in many inflammatory diseases. The purpose of this narrative review is to highlight the knowledge on the use of HS approaches against viral infection over the past years and to describe the mechanisms involved in the release of neutrophil extracellular traps (NETs) and production of cytokine in severe lung diseases, such as COVID-19. We reported the consequences of hyponatremia in COVID-19 patients, and the immunomodulatory effects of HS, either in vitro or in vivo. We also described the relationship between electrolyte disturbances and COVID-19 infection. Although there is still a lack of clinical trials, hypertonic NaCl solutions have marked effects on neutrophil function and NETs formation, emerging as a promising adjuvant therapy in COVID-19.

【 授权许可】

Unknown