A prospective study of salvational intervention with ICS/LABA for reducing chronic obstructive pulmonary disease exacerbation under severe air pollution (SIRCAP) in Beijing: protocol of a multi-center randomized controlled trial

BMC Pulmonary Medicine

Xueying Li¹  Xiaoguang Wang²  Fengzhen Zhang²  Xiangxin Li³  Chunxiao Yu⁴  Senlin Wang⁵  Xiaosen Qian⁶  Yongxiang Zhang⁷  Xinsheng Chen⁸  Li Dai⁹  Guoguang Xia⁹  Zhenyang Xu^1,10  Jiping Liao^1,11  Tianyu Zhou^1,11  Yijue Zhong^1,11  Guangfa Wang^1,11  Pingchao Xiang^1,12 

[1] Department of Medical Statistics, Peking University First Hospital;Department of Respiratory Medicine, Aerospace 731 Hospital;Department of Respiratory Medicine, Beijing Changping Hospital;Department of Respiratory Medicine, Beijing Jingmei Group General Hospital;Department of Respiratory Medicine, Beijing Miyun Hospital;Department of Respiratory Medicine, Civil Aviation General Hospital;Department of Respiratory Medicine, People’s Hospital of Beijing Daxing District;Department of Respiratory Medicine, The Hospital of Shunyi District Beijing;Department of Respiratory and Critical Care Medicine, Beijing Jishuitan Hospital;Department of Respiratory and Critical Care Medicine, Beijing Luhe Hospital capital medical university;Department of Respiratory and Critical Care Medicine, Peking University First Hospital;Department of Respiratory and Critical Care Medicine, Peking University Shougang hospital;

关键词: COPD;    AECOPD;    Air pollution;    Budesonide/Formoterol;    Salvational intervention;   

DOI  :  10.1186/s12890-018-0771-9

来源: DOAJ

【 摘 要 】

Abstract Background Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality all over the world. Acute exacerbation of COPD (AECOPD) not only accelerates the progression of disease, but also causes hospital administration and death events. Epidemiologic studies have shown air pollution is a high risk factor of AECOPD. However, there are rare technics or treatment strategies recommended to reduce severe air pollution related AECOPD. Methods This is a multi-center, prospective, randomized and standard treatment parallel control clinical trial. Seven hundred sixty-four stable COPD patients in group B, C and D according to GOLD 2017 will be recruited and equally divided into two parallel groups, salvational intervention (SI group) and control group (CT group). Original treatments for participants include tiotropium (18μg once q.d), budesonide/formoterol (160μg/4.5μg once or twice b.i.d) or budesonide/formoterol (160μg/4.5μg once or twice b.i.d) with tiotropium (18μg once q.d). The savational intervention for SI group is routine treatment plus budesonide/formoterol (160μg/4.5μg once b.i.d) from the first day after severe air pollution (air quality index, AQI ≥200) to the third day after AQI < 200. CT group will maintain the original treatment. The intervention will last for 2 years. Primary outcome is the frequency of AECOPD per year and the secondary outcomes include the incidence of unplanned outpatient visits, emergency visits, hospitalization, medical cost and mortality associated with AECOPD per year. Discussion The salvational intervention is a novel strategy for COPD management under severe air pollution. Results of the present study will provide reference information to guide clinical practice in reducing the air pollution related exacerbation of COPD. Trial registration This study has been registered at www.ClinicalTrials.gov (registration identifier: NCT03083067) in 17 March, 2017.

【 授权许可】

Unknown