Effect of antiretroviral therapy on allele-associated Lp(a) level in women with HIV in the Women's Interagency HIV Study

Journal of Lipid Research

Erdembileg Anuurad¹  Brad Aouizerat²  Dan Merenstein³  Jason Lazar⁴  Lars Berglund⁵  Roksana Karim⁶  Adaora A. Adimora⁷  Kenneth Butler⁸  Mardge Cohen⁹  Wei Zhang^1,10  Chin-Shang Li^1,10  Savita Pahwa^1,11  Elizabeth Golub^1,12  Igho Ofotokun^1,13  Robert Kaplan^1,14  Byambaa Enkhmaa^1,15 

[1] Departments of Internal Medicine University of California, Davis, Davis, CA 95616;Department Preventive Medicine, University of Southern California, Los Angeles, Los Angeles, CA 90007;Department of Cardiovascular Disease, State University of New York Downstate Medical Center, Brooklyn, NY 11203;Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461;Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205;Department of Family Medicine, Georgetown University Medical Center, Washington, DC 20007;Department of Medicine, Infectious Diseases, Emory School of Medicine, Atlanta, GA 30307;Department of Medicine, Rush University and Stroger Hospital, Cook County Bureau of Health Services, Chicago, IL 60612;Department of Oral and Maxillofacial Surgery, New York University, New York, NY 10003;Departments of Internal Medicine University of California, Davis, Davis, CA 95616;Division of Geriatric Medicine/Gerontology, University of Mississippi Medical Center, Jackson, MS 39216;Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599;Miami Center for AIDS Research, University of Miami, Miami, FL 33136;Public Health Sciences, University of California, Davis, Davis, CA 95616;To whom correspondence should be addressed.;

关键词: apolipoproteins;    lipoproteins;    drug therapy;    clinical studies;    molecular biology/genetics;    apolipoprotein (a) sizes;   

DOI  :  

来源: DOAJ

【 摘 要 】

We previously demonstrated an association between lipoprotein (a) [Lp(a)] levels and atherosclerosis in human immunodeficiency virus (HIV)-seropositive women. The effects of antiretroviral therapy (ART) on Lp(a) levels in relation to apo(a) size polymorphism remain unclear. ART effects on allele-specific apo(a) level (ASL), an Lp(a) level associated with individual apo(a) alleles within each allele-pair, were determined in 126 HIV-seropositive women. ART effects were tested by a mixed-effects model across pre-ART and post-ART first and third visits. Data from 120 HIV-seronegative women were used. The mean age was 38 years; most were African-American (∼70%). Pre-ART ASLs associated with the larger (4.6 mg/dl vs. 8.0 mg/dl, P = 0.024) or smaller (13 mg/dl vs. 19 mg/dl, P = 0.041) apo(a) sizes were lower in the HIV-seropositive versus HIV-seronegative group, as was the prevalence of a high Lp(a) level (P = 0.013). Post-ART ASL and prevalence of high Lp(a) or apo(a) sizes and frequency of small size apo(a) (≤22 kringles) did not differ between the two groups. ART increased Lp(a) level (from 18 to 24 mg/dl, P < 0.0001) and both ASLs (P < 0.001). In conclusion, regardless of genetic control, Lp(a) can be modulated by HIV and its treatment. ART initiation abrogates HIV-induced suppression of Lp(a) levels and ASLs, contributing to promote CVD risk in HIV-seropositive individuals.

【 授权许可】

Unknown