Perfusion Imaging of Fatigue and Time-on-Task Effects in Patients With Parkinson’s Disease

Frontiers in Aging Neuroscience

Rupal Bhavsar¹  Wanting Liu¹  David Raizen¹  John A. Detre¹  Hengyi Rao¹  Tianxin Mao¹  Jianghong Liu³  Daniel Weintraub⁴  Eugenia Mamikonyan⁴ 

[1] Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States;Center for Magnetic Resonance Imaging Research and Key Laboratory of Applied Brain and Cognitive Sciences, School of Business and Management, Shanghai International Studies University, Shanghai, China;Department of Family and Community Health, University of Pennsylvania School of Nursing, Philadelphia, PA, United States;Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States;School of Psychology, South China Normal University, Guangzhou, China;

关键词: psychomotor vigilance test;    Parkinson’s disease;    fatigue;    time-on-task effect;    ASL perfusion fMRI;    frontoparietal network;   

DOI  :  10.3389/fnagi.2022.901203

来源: DOAJ

【 摘 要 】

Fatigue is a highly prevalent and debilitating non-motor symptom in Parkinson’s disease (PD), yet its’ neural mechanisms remain poorly understood. Here we combined arterial spin labeling (ASL) perfusion functional magnetic resonance imaging (fMRI) with a sustained mental workload paradigm to examine the neural correlates of fatigue and time-on-task effects in PD patients. Twenty-one PD patients were scanned at rest and during continuous performance of a 20-min psychomotor vigilance test (PVT). Time-on-task effects were measured by the reaction time changes during the PVT and by self-reported fatigue ratings before and after the PVT. PD subjects demonstrated significant time-on-task effects, including progressively slower reaction time on the PVT and increased post-PVT fatigue ratings compared to pre-PVT. Higher levels of general fatigue were associated with larger increases in mental fatigue ratings after the PVT. ASL imaging data showed increased CBF in the right middle frontal gyrus (MFG), bilateral occipital cortex, and right cerebellum during the PVT compared to rest, and decreased CBF in the right MFG at post-task rest compared to pre-task rest. The magnitude of regional CBF changes in the right MFG and right inferior parietal lobe correlated with subjective fatigue rating increases after the PVT task. These results demonstrate the utility of continuous PVT paradigm for future studies of fatigue and cognitive fatigability in patients, and support the key role of the fronto-parietal attention network in mediating fatigue in PD.

【 授权许可】

Unknown