Effect of Weight Loss after Bariatric Surgery on Thyroid-Stimulating Hormone Levels in Euthyroid Patients with Morbid Obesity

Nutrients

Sonia Pértega¹  Enrique Mena²  María Jesús García-Brao²  Elena Outeiriño-Blanco³  Susana Sangiao-Alvarellos⁴  Fernando Cordido⁴  Bárbara María Varela-Rodriguez⁴  María Cordido⁴  Lara Pena-Bello⁴  Paula Juiz-Valiña⁴ 

[1] Clinical Epidemiology and Biostatistics Unit, University Hospital A Coruña, 15006 A Coruña, Spain;Department of Digestive and General Surgery, University Hospital A Coruña, 15006 A Coruña, Spain;Department of Endocrinology, University Hospital A Coruña, 15006 A Coruña, Spain;Endocrine, Nutritional and Metabolic Diseases Group, Faculty of Health Sciences, University of A Coruña, 15006 A Coruña, Spain;

关键词: obesity;    weight loss;    bariatric surgery;    thyroid;    TSH;   

DOI  :  10.3390/nu11051121

来源: DOAJ

【 摘 要 】

Obesity is associated with several endocrine abnormalities, including thyroid dysfunction. The objective of this study was to investigate the effect of weight loss after bariatric surgery on thyroid-stimulating hormone (TSH) levels in euthyroid patients with morbid obesity. We performed an observational study, evaluating patients with morbid obesity submitted to bariatric surgery. We included 129 patients (92 women) and 31 controls (21 women). Clinical, anthropometric, biochemical, and hormonal parameters were evaluated. The primary endpoint was circulating TSH (µU/mL). Fasting TSH levels were higher in the obese group (3.3 ± 0.2) than in the control group (2.1 ± 0.2). The mean excessive body mass index (BMI) loss (EBMIL) 12 months after bariatric surgery was 72.7 ± 2.1%. TSH levels significantly decreased in the obese patients after surgery; 3.3 ± 0.2 vs. 2.1 ± 0.2 before and 12 months after surgery, respectively. Free thyroxine (T4) (ng/dL) levels significantly decreased in the obese patients after surgery; 1.47 ± 0.02 vs. 1.12 ± 0.02 before and 12 months after surgery, respectively. TSH decreased significantly over time, and the decrement was associated with the EBMIL. In euthyroid patients with morbid obesity, weight loss induced by bariatric surgery promotes a significant decline of the increased TSH levels. This decrement of TSH is progressive over time after surgery and significantly associated with excess BMI loss.

【 授权许可】

Unknown