A Journey to the Conformational Analysis of T-Cell Epitope Peptides Involved in Multiple Sclerosis

Brain Sciences

Sofia Kiriakidi¹  Thomas Mavromoustakos¹  Catherine Koukoulitsa¹  Eleni Chontzopoulou¹  AndreasG. Tzakos² 

[1] Department of Chemistry, National and Kapodistrian University of Athens, 15784 Zographou, Athens, Greece;Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110e Ioannina, Greece;

关键词: conformational analysis;    peptides;    altered peptide ligands;    multiple sclerosis;    MS;    NMR spectroscopy;   

DOI  :  10.3390/brainsci10060356

来源: DOAJ

【 摘 要 】

Multiple sclerosis (MS) is a serious central nervous system (CNS) disease responsible for disability problems and deterioration of the quality of life. Several approaches have been applied to medications entering the market to treat this disease. However, no effective therapy currently exists, and the available drugs simply ameliorate the destructive disability effects of the disease. In this review article, we report on the efforts that have been conducted towards establishing the conformational properties of wild-type myelin basic protein (MBP), myelin proteolipid protein (PLP), myelin oligodendrocyte glycoprotein (MOG) epitopes or altered peptide ligands (ALPs). These efforts have led to the aim of discovering some non-peptide mimetics possessing considerable activity against the disease. These efforts have contributed also to unveiling the molecular basis of the molecular interactions implicated in the trimolecular complex, T-cell receptor (TCR)–peptide–major histocompatibility complex (MHC) or human leucocyte antigen (HLA).

【 授权许可】

Unknown