Identification and Characterization of Two New Degradation Products of Saikosaponin A under Acid Hydrolytic Conditions

Molecules

Jun Li¹  Hua Jiang¹  Qiang Xu¹ 

[1] College of Chemistry and Pharmaceutical Engineering, Henan University of Science and Technology, Luoyang 471023, China;

关键词: acid hydrolysis;    degradation product;    saikosaponin A;   

DOI  :  10.3390/molecules21091232

来源: DOAJ

【 摘 要 】

Saikosaponin (SS) A is a compound with various pharmacological properties and is easily degraded into SS-B1 and SS-G under acid conditions. In the present work, two new degradation products of SS-A, formed under acid hydrolytic conditions, were detected and isolated using analytical and semi-preparative liquid chromatography technology; furthermore, their structures were characterized as hydroxy-saikosaponin A and SS-B2 by spectral analysis, which is not only essential in stability-indicating method development and validation, but also could be used as a worst case scenario to assess the analytical method performance of SS-A. Moreover, their structural transformation pathways are also proposed.

【 授权许可】

Unknown