Isolation, Structural Analyses and Biological Activity Assays against Chronic Lymphocytic Leukemia of Two Novel Cytochalasins — Sclerotionigrin A and B

Molecules

Charlotte H. Gotfredsen¹  Thomas O. Larsen²  Lene M. Petersen²  Tanja T. Bladt²  Jens C. Frisvad²  Martina Seiffert³  Claudia Dürr³ 

[1] Department of Chemistry, Technical University of Denmark, Kemitorvet, B201,DK-2800 Kgs. Lyngby, Denmark;Department of Systems Biology, Technical University of Denmark, Søltofts Plads B221,DK-2800 Kgs. Lyngby, Denmark;German Cancer Research Center, Molecular Genetics, Im Neuenheimer Feld 280,D-69120 Heidelberg, Germany;

关键词: cytochalasins;    apergilli;    Apsergillus sclerotioniger;    chronic lymphocytic leukemia;   

DOI  :  10.3390/molecules19079786

来源: DOAJ

【 摘 要 】

Two new cytochalasins, sclerotionigrin A (1) and B (2) were isolated together with the known proxiphomin (3) from the filamentous fungus Aspergillus sclerotioniger. The structures and relative stereochemistry of 1 and 2 were determined based on comparison with 3, and from extensive 1D and 2D NMR spectroscopic analysis, supported by high resolution mass spectrometry (HRMS). Compounds 2 and 3 displayed cytotoxic activity towards chronic lymphocytic leukemia cells in vitro, with 3 being the most active.

【 授权许可】

Unknown