Myostatin gene promoter: structure, conservation and importance as a target for muscle modulation

Journal of Animal Science and Biotechnology

Carolina Stefano Mantovani¹  Lúcia Elvira Alvares¹  Carla Vermeulen Carvalho Grade² 

[1] Departamento de Bioquímica e Biologia Tecidual, Universidade Estadual de Campinas – UNICAMP;Universidade Federal da Integração Latino-Americana, UNILA, Instituto Latino-Americano de Ciências da Vida e da Natureza;

关键词: CAAT box;    E-box;    Gene promoter;    Myogenesis;    Myostatin;    SNP;   

DOI  :  10.1186/s40104-019-0338-5

来源: DOAJ

【 摘 要 】

Abstract Myostatin (MSTN) is one of the key factors regulating myogenesis. Because of its role as a negative regulator of muscle mass deposition, much interest has been given to its protein and, in recent years, several studies have analysed MSTN gene regulation. This review discusses the MSTN gene promoter, focusing on its structure in several animal species, both vertebrate and invertebrate. We report the important binding sites considering their degree of phylogenetic conservation and roles they play in the promoter activity. Finally, we discuss recent studies focusing on MSTN gene regulation via promoter manipulation and the potential applications they have both in medicine and agriculture.

【 授权许可】

Unknown