A Review of Structural and Biomechanical Changes in the Cornea in Aging, Disease, and Photochemical Crosslinking

Frontiers in Bioengineering and Biotechnology

Brecken J. Blackburn²  William J. Dupps²  Andrew M. Rollins²  Michael W. Jenkins⁵ 

[1] Cole Eye Institute, Cleveland Clinic, Cleveland, OH, United States;Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States;Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States;Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine of CWRU, Cleveland, OH, United States;Department of Pediatrics, Case Western Reserve University, Cleveland, OH, United States;

关键词: cornea biomechanical properties;    cornea;    aging;    crosslinking;    crosslinking (CXL) corneal collagen;    keratoconus;   

DOI  :  10.3389/fbioe.2019.00066

来源: DOAJ

【 摘 要 】

The study of corneal biomechanics is motivated by the tight relationship between biomechanical properties and visual function within the ocular system. For instance, variation in collagen fibril alignment and non-enzymatic crosslinks rank high among structural factors which give rise to the cornea's particular shape and ability to properly focus light. Gradation in these and other factors engender biomechanical changes which can be quantified by a wide variety of techniques. This review summarizes what is known about both the changes in corneal structure and associated changes in corneal biomechanical properties in aging, keratoconic, and photochemically crosslinked corneas. In addition, methods for measuring corneal biomechanics are discussed and the topics are related to both clinical studies and biomechanical modeling simulations.

【 授权许可】

Unknown