C‐Reactive Protein Identifies Low‐Risk Metabolically Healthy Obese Persons: The European Prospective Investigation of Cancer–Norfolk Prospective Population Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Benoit J. Arsenault¹  S. Matthijs Boekholdt²  Sara Ahmadi‐Abhari³  Diederik F. van Wijk⁴  Erik S. G. Stroes⁴  Kay‐Tee Khaw⁵  Nicholas J. Wareham⁵ 

[1] Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada;Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands;Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, United Kingdom;Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands;Medical Research Council Epidemiology Unit, Cambridge, United Kingdom;

关键词: atherosclerosis;    inflammation;    metabolic syndrome;    obesity;    risk factor;   

DOI  :  10.1161/JAHA.115.002823

来源: DOAJ

【 摘 要 】

BackgroundConflicting data exist about the cardiovascular risk of metabolically healthy obese persons. The prognostic value of C‐reactive protein (CRP) in this intriguing group is unknown. We assessed the association between CRP levels and the risk of coronary heart disease (CHD) in metabolically healthy persons with abdominal obesity. Methods and ResultsIn the European Prospective Investigation of Cancer–Norfolk prospective cohort, CRP levels and information on metabolic syndrome criteria were available for 7279 participants, of whom 825 (11%) developed CHD during a follow‐up period of 10.9±1.8 years. There was a trend toward a higher multivariable‐adjusted hazard ratio for CHD in metabolically healthy obese participants with CRP levels >2 mg/L compared with <2 mg/L (hazard ratio 1.59, 95% CI 0.97–2.62, P=0.066). Metabolically unhealthy obese participants had significantly higher CHD risk compared with metabolically healthy obese participants with CRP levels <2 mg/L (hazard ratio 1.88, 95% CI 1.20–2.94, P=0.006). Most important, we found that the risk of CHD among metabolically healthy obese persons with CRP levels <2 mg/L was comparable to that of metabolically healthy nonobese persons (hazard ratio 0.91, 95% CI 0.60–1.39, P=0.674). ConclusionsAmong metabolically healthy obese persons, low CRP levels were associated with a CHD risk comparable to that of metabolically healthy nonobese persons. CRP appears to be an easy and widely available method for identifying a low‐risk subpopulation among metabolically healthy obese persons.

【 授权许可】

Unknown