Melanoma in Adolescents and Young Adults: Evaluation of the Characteristics, Treatment Strategies, and Prognostic Factors in a Monocentric Retrospective Study

Frontiers in Oncology

Jacopo Pigozzo¹  Lorenzo Nicolè²  Luigi Dall’Olmo³  Daniela Di Carlo⁴  Marco Rastrelli⁴  Clara Benna⁴  Gianni Bisogno⁵  Mauro Alaibac⁶  Angelo Paolo Dei Tos⁶  Alessandra Buja⁷  Alessandro Dal Monico⁹  Irene Russo^1,10  Simone Mocellin^1,10  Francesco Cavallin^1,11  Rocco Cappellesso^1,12  Beatrice Ferrazzi^1,13  Claudia Di Prata^1,14  Paolo Del Fiore^1,14  Chiara Menin^1,14  Antonella Vecchiato^1,14  Sabrina Carraro^1,14  Alessandra Collodetto^1,14  Romina Spina^1,14  Saveria Tropea^1,14  Francesco Russano^1,14  Angela Filoni^1,14  Vanna Chiarion-Sileni^1,15 

[1] Cytopathology, Ospedale dell’Angelo, Mestre, Italy;Cytopathology, University of Padua, Padua, Italy;0Melanoma Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy;1Department of Surgery, Oncology and Gastroenterology (DISCOG), University of Padua, Padua, Italy;2Immunology and Diagnostic Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy;3Hematology/Oncology Division, Department of Women’s and Children’s Health, University of Padua, Padua, Italy;Department of Cardiological, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy;;Department of Medicine (DIMED), Unit of Pathology &Department of Medicine, University of Padua School of Medicine and Surgery, Padua, Italy;Division of Dermatology, Department of Medicine (DIMED), University of Padua, Padua, Italy;Independent Statistician, Solagna, Italy;Pathological Anatomy Unit, University Hospital of Padua, Padua, Italy;Postgraduate School of Occupational Medicine, University of Verona, Verona, Italy;Soft-Tissue, Peritoneum and Melanoma Surgical Oncology Unit, Veneto Institute of Oncology - IOV IRCCS, Padua, Italy;;Unit of Surgical Pathology &

关键词: melanoma;    skin cancer;    AYA;    adolescent and young adult oncology;    adolescent and young adult melanoma;    survival;   

DOI  :  10.3389/fonc.2021.725523

来源: DOAJ

【 摘 要 】

The “Veneto Cancer Registry” records melanoma as the most common cancer diagnosed in males and the third common cancer in females under 50 years of age in the Veneto Region (Italy). While melanoma is rare in children, it has greater incidence in adolescents and young adults (AYA), but literature offers only few studies specifically focused on AYA melanoma. The aim of this study was to describe the characteristics, surgical treatment, and prognosis of a cohort of AYA melanoma in order to contribute to the investigation of this malignancy and provide better patient care. This retrospective cohort study included 2,752 Caucasian patients (702 AYA and 2,050 non-AYA patients) from the Veneto Region who were over 15 years of age at diagnosis, and who received diagnosis and/or treatment from our institutions between 1998 and 2014. Patients were divided in adolescents and youth (15-25 years), young adults (26-39 years) and adults (more than 39 years) for the analysis. We found statistically significant differences in gender, primary site, Breslow thickness, ulceration, pathologic TNM classification (pTNM) stage and tumor subtype among the age groups. Disease-specific survival and disease-free survival were also different among the age groups. Our findings suggest that the biological behavior of melanoma in young people is different to that in adults, but not such as to represent a distinct pathological entity. Additional and larger prospective studies should be performed to better evaluate potential biological and cancer-specific differences between AYAs and the adult melanoma population.

【 授权许可】

Unknown