Archives of Medicine and Health Sciences | |
Antianxiety effect of ethanolic extract of leaves of Moringa oleifera in Swiss albino mice | |
关键词: Anxiety; swiss albino mice; moringa oleifera; ethanolic extract; anxiolytic activity; | |
DOI : 10.4103/2321-4848.133771 | |
来源: DOAJ |
【 摘 要 】
Background: Anxiety disorder is one of the most common mental ailments exhibited by humans. It can cause considerable distress and debility. Anxiety is portrayed as a frame of mind concerned about future in association with preparation for possible, upcoming undesirable happenings. The present treatment for the disorder is having a lot of side-effects. An agent with good therapeutic effect and less side-effects is needed for the treatment of anxiety. Objectives: To investigate the anxiolytic activity of ethanolic extract of Moringa oleifera leaves in Swiss albino mice. Materials and Methods: The ethanolic extract of leaves of Moringa oleifera (200 mg/kg, i.p) was studied for its anxiolytic effect on Swiss albino mice by using Elevated Plus Maze (EPM) and Light Dark Arena (LDA) test. Results: The ethanolic extract of the leaves of Moringa oleifera (200 mg/kg, i.p) demonstrated significant (P < 0.001) anxiolytic activity in EPM and LDA models of anxiety. Conclusion: The data suggests that the ethanolic extract of Moringa oleifera leaves may have produced its anxiolytic effects via multiple mechanisms.
【 授权许可】
Unknown