Clinical and histological evaluations of the effects of concentrated growth factor combined with deproteinated bovine bone mineral in site preservation

口腔疾病防治

WANG Lianfei¹  LI Xiao²  CHENG Gang³ 

[1] Department of Stomatology, The First People’s Hospital of Linan District;School of Stomatology, Bengbu Medical University;1.School of Stomatology, Bengbu Medical University2.Department of Stomatology, Zhejiang Provincial People’s Hospital;

关键词: dental implantation;    site preservation;    bone substitute;    deproteinated bovine bone mineral;    bio-oss;    bio-gide collagen membrane;    guided bone regeneration;    concentrated growth factor;    new bone;    histomorphometry;   

DOI  :  10.12016/j.issn.2096-1456.2022.06.005

来源: DOAJ

【 摘 要 】

Objective To evaluate the osteogenic effect of concentrated growth factor (CGF) combined with deproteinated bovine bone mineral (DBBM) in site preservation using clinical and histomorphometric observations. Methods A total of 26 patients who needed extraction of affected teeth and received staged implantation after site preservation were selected. The patients were randomly divided into the DBBM group (Bio-Oss was implanted simultaneously after extraction) and CGF+DBBM group (CGF+Bio-Oss was implanted simultaneously after extraction), with 13 patients in each group, and both groups were covered with Bio-Gide collagen membrane. Cone beam computed tomography (CBCT) was performed preoperatively and 6 months later to measure the changes in alveolar bone height and width, and the bone specimens were drilled 6 months after site preservation during implant surgery for histological analyses. Results CBCT showed that the height and width of alveolar bone were absorbed 6 months after site preservation in the CGF+DBBM and DBBM groups, and the reduction in alveolar ridge width in the CGF+DBBM group was statistically less than the DBBM group (P <0.05). The histomorphometry results showed that the percentage of new bone in the CGF+DBBM and DBBM groups were 35.30% ± 3.56% and 26.38% ± 5.04%, respectively, and the amount of new bone in the CGF+DBBM group was statistically higher than the DBBM group (P<0.05). Conclusion CGF combined with DBBM is superior to DBBM in maintaining the alveolar bone volume and shape in site preservation, which creates favorable conditions for implant restoration.

【 授权许可】

Unknown