Technetium Complexes and Radiopharmaceuticals with Scorpionate Ligands

Molecules

Adriano Duatti¹  Micol Pasquali²  Alessandra Boschi²  Licia Uccelli²  Melchiore Giganti²  Petra Martini² 

[1] Department of Chemical and Pharmaceutical Sciences, University of Ferrara, 44121 Ferrara, Italy;Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy;

关键词: scorpionate ligands;    technetium;    Tc cores;    Tc-99m radiopharmaceuticals;   

DOI  :  10.3390/molecules23082039

来源: DOAJ

【 摘 要 】

Scorpionate ligands have played a crucial role in the development of technetium chemistry and, recently, they have also fueled important advancements in the discovery of novel diagnostic imaging agents based on the γ-emitting radionuclide technetium-99m. The purpose of this short review is to provide an illustration of the most general and relevant results in this field, however without being concerned with the details of the analytical features of the various compounds. Thus, emphasis will be given to the description of the general features of technetium complexes with scorpionate ligands including coordination modes, structural properties and an elementary bonding description. Similarly, the most relevant examples of technetium-99m radiopharmaceuticals derived from scorpionate ligands and their potential interest for nuclear imaging will be summarized.

【 授权许可】

Unknown