Parental warmth interacts with several genes to affect executive function components: a genome-wide environment interaction study

BMC Genetics

Chuansheng Chen¹  Libo Zhao²  Shudong Zhang³  Qi Dong⁴  Gui Xue⁴  Chunhui Chen⁴ 

[1] Department of Psychological Science, University of California;Department of Psychology, BeiHang University;Faculty of Education, Beijing Normal University;State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University;

关键词: Executive function;    Parental warmth;    Gene set enrichment analysis;    Gene-environment interaction;   

DOI  :  10.1186/s12863-020-0819-8

来源: DOAJ

【 摘 要 】

Abstract Background Executive function (EF) is vital to human beings. It has been linked to many genes and family environmental factors in separate studies, but few studies have examined the potential interactions between gene(s) and environmental factor(s). The current study explored the whole genome to identify SNPs, genes, and pathways that interacted with parental warmth (PW) on EF. Results Nine EF tasks were used to measure its three components (common EF, updating, shifting) based on the model proposed by Miyake et al. (2000). We found that rs111605473, LAMP5, SLC4A7, and LRRK1 interacted significantly with PW to affect the updating component of EF, and the GSE43955 pathway interacted significantly with PW to affect the common EF component. Conclusions The current study is the first to identify genes that interacted with PW to affect EF. Further studies are needed to reveal the underlying mechanism.

【 授权许可】

Unknown