Preferences for Outcomes Among Adults with Type 1 Diabetes and Caregivers of Children with Type 1 Diabetes

Patient Preference and Adherence

关键词: type 1 diabetes;    discrete choice;    adults;    caregivers;    stated preferences;   

DOI  :  

来源: DOAJ

【 摘 要 】

Marjana Marinac,1 Jessie Sutphin,2 Campbell Hutton,1 Kathleen Klein,2 Sean Sullivan,3 Carol Mansfield2 1JDRF, Washington, DC, USA; 2RTI Health Solutions, Research Triangle Park, NC, USA; 3The Leona M. and Harry B. Helmsley Charitable Trust, New York, NY 10169, USACorrespondence: Carol Mansfield Email [e-mail]: Hemoglobin A1c (HbA1c) is the accepted measure of effectiveness for type 1 diabetes therapies. We investigated preferences for measures of diabetes control in addition to HbA1c among adults with type 1 diabetes and caregivers of children with type 1 diabetes.Methods: Using discrete-choice experiment methodology, surveys for adults with type 1 diabetes and caregivers presented choices between hypothetical treatments described by six attributes with varying levels: HbA1c, time in optimal glucose range, weekly number and severity of hypoglycemic and hyperglycemic events, additional disease management time, and additional treatment cost. Choice data were analyzed using random-parameters logit.Results: A total of 300 adults with type 1 diabetes and 400 caregivers completed the survey. Adults and caregivers placed the most importance on reducing hypoglycemic and hyperglycemic events. For adults, avoiding 1– 5 mild-to-moderate hypoglycemic events (glucose 54– 69 mg/dL)/week was five times more important than being a half-point above target HbA1c. Avoiding 1– 5 hyperglycemic events (glucose > 180 mg/dL)/week was seven times more important than being a half-point above target HbA1c. Additional time in optimal glucose range was as important as a reduction greater than a half-point in HbA1c. Avoiding hyperglycemic and hypoglycemic events was more important than all other outcomes for caregivers of younger children. Caregivers of children > 12 years placed relatively more weight on avoiding hypoglycemic events < 54 mg/dL than those with younger children and preferred avoiding additional costs.Conclusion: Adults with type 1 diabetes and caregivers prioritize controlling hypoglycemic and hyperglycemic events, including mild-to-moderate events. These preferences should be considered in drug development and regulatory decisions.Keywords: type 1 diabetes, discrete choice, adults, caregivers, stated preferences

【 授权许可】

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