Sarcoma as Second Cancer in a Childhood Cancer Survivor: Case Report, Large Population Analysis and Literature Review

Medicina

Siddhartha Yavvari¹  Eduardo Urias²  Teresia Pham²  Thinh H. Nguyen²  Narendra Panapitiya²  Mohamad M. Al-Rahawan²  Maninder Kaur²  Monish Ram Makena³ 

[1] Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA;Department of Pediatrics, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX 79430, USA;Department of Physiology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA;

关键词: sarcoma;    second cancer;    hepatoblastoma;    pediatric;    SEER;   

DOI  :  10.3390/medicina56050224

来源: DOAJ

【 摘 要 】

The majority of pediatric patients are cured of their primary cancer with current advanced developments in pediatric cancer therapy. However, survivors often experience long-term complications from therapies for primary cancer. The delayed mortality rate has been decreasing with the effort to reduce the therapeutic exposure of patients with pediatric cancers. Our study investigates the incidence of sarcoma as second cancer in pediatric cancer survivors. We present a 9-year-old male who survived embryonal hepatoblastoma diagnosed at 22 months of age. At 4.5 years of age, he presented with a non-metastatic primitive neuroectodermal tumor (PNET) of the left submandibular area. He has no evidence of recurrence of either cancer for 51 months after finishing all chemotherapy and radiotherapy. We used the Surveillance, Epidemiology, and End Results (SEER) database to identify the current rate of second sarcomas in pediatric cancer survivors. Our literature review and large population analysis emphasize the impact of sarcoma as a second malignancy and provide help to physicians caring for pediatric cancer survivors.

【 授权许可】

Unknown