Tafenoquine and primaquine do not exhibit clinical neurologic signs associated with central nervous system lesions in the same manner as earlier 8-aminoquinolines

Malaria Journal

Geoffrey Dow¹  Tracey Brown²  Jonathan Berman³  Stephen Toovey⁴ 

[1] 60°Pharmaceuticals LLC;Clinical Network Services Pty Ltd;Fast-Track Drugs & Biologics;Pegasus Research;

关键词: 8-aminoquinoline;    Neurotoxicity;    Brain-stem;    Neurohistopathology;    Malaria;    Primaquine;   

DOI  :  10.1186/s12936-018-2555-3

来源: DOAJ

【 摘 要 】

Abstract Background Tafenoquine was recently approved for Plasmodium vivax radical cure (KRINTAFEL™) and malaria prevention (ARAKODA™). Methods A review of the non-clinical and clinical literature was conducted to assess whether tafenoquine (and primaquine) exhibit the same neurologic lesions and associated clinical signs as earlier 8-aminoquinolines, as has been alleged in recent opinion pieces. Results Plasmocid, pamaquine and pentaquine damage specific neuro-anatomical structures in Rhesus monkeys and humans leading to corresponding deficits in neurologic function. Neurologic therapeutic indices for these 3 drugs calculated based on monkey data were well correlated with human data. Despite 60 years of use, there is no evidence that primaquine exhibits similar neurotoxicity in humans. Discussion/conclusions Extrapolation of data from Rhesus monkeys to humans, and the available clinical data, suggest that tafenoquine also does not exhibit pamaquine, pentaquine or plasmocid-like clinical neurologic signs in humans.

【 授权许可】

Unknown