The Lymphatic System in Zebrafish Heart Development, Regeneration and Disease Modeling

Journal of Cardiovascular Development and Disease

MichaelR. M. Harrison¹  CarolineA. Pearson²  Xidi Feng³  Ching-Ling Lien³  Stanislao Travisano³ 

[1] Cardiovascular Research Institute, Weill Cornell Medical College, New York, NY 10021, USA;Laboratory of Neurogenetics and Development, Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY 10021, USA;The Saban Research Institute of Children’s Hospital Los Angeles, Los Angeles, CA 90027, USA;

关键词: cardiac lymphatic vessels;    zebrafish;    heart;    development;    regeneration;   

DOI  :  10.3390/jcdd8020021

来源: DOAJ

【 摘 要 】

Heart disease remains the single largest cause of death in developed countries, and novel therapeutic interventions are desperately needed to alleviate this growing burden. The cardiac lymphatic system is the long-overlooked counterpart of the coronary blood vasculature, but its important roles in homeostasis and disease are becoming increasingly apparent. Recently, the cardiac lymphatic vasculature in zebrafish has been described and its role in supporting the potent regenerative response of zebrafish heart tissue investigated. In this review, we discuss these findings in the wider context of lymphatic development, evolution and the promise of this system to open new therapeutic avenues to treat myocardial infarction and other cardiopathologies.

【 授权许可】

Unknown