Exploring the Phytochemicals of Acacia melanoxylon R. Br.

Plants

Cecília M. P. Rodrigues¹  Joana Gonçalves¹  Sidónio Duarte²  Ana Lourenço²  Patrícia Máximo²  Diana Alves²  Pedro Arsénio³ 

[1] Faculty of Pharmacy, Research Institute for Medicines (iMed.ULisboa), Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal;LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, NOVA University, 2829-516 Caparica, Portugal;Linking Landscape, Environment, Agriculture and Food (LEAF)—Research Center, Associated Laboratory TERRA, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017 Lisbon, Portugal;

关键词: invasive species;    Acacia melanoxylon;    terpenoids;    HCT116 human colorectal cancer cells;    cytotoxicity;   

DOI  :  10.3390/plants10122698

来源: DOAJ

【 摘 要 】

Invasive species are currently a world menace to the environment, although the study of their chemistry may provide a means for their future beneficial use. From a study of Portuguese Acacia melanoxylon R. Br. five known compounds were isolated: lupeol, 3β-Z-coumaroyl lupeol, 3β-E-coumaroyl lupeol (dioslupecin A), kolavic acid 15-methyl ester and vomifoliol (blumenol A). Their structures were elucidated by 1D and 2D NMR spectroscopy and mass spectrometry, and as a result some corrections are made to their previous ¹³C NMR assignments. Cytotoxicity of 3β-E-coumaroyl lupeol (dioslupecin A) and kolavic acid 15-methyl ester was evaluated against HCT116 human colorectal cancer cells although biological activity was not evident.

【 授权许可】

Unknown