Leukaemia Cutis: Clinical Features and Outcomes of 56 Patients

Acta Dermato-Venereologica

Ji Hyun Lee¹  Joon Ho Son¹  Ju Hee Han¹  Nack-Gyun Chung¹  Hee Je Kim¹  Young Min Park¹  Yeong Ho Kim¹  Chul Hwan Bang² 

[1] ;Department of Dermatology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Korea;

关键词: leukemia cutis;    prognosis;    leukemia;    acute myelogenous leukemia;    acute lymphoblastic leukemia;   

DOI  :  10.2340/actadv.v102.1123

来源: DOAJ

【 摘 要 】

Leukaemia is a malignant neoplasm of the haematopoietic system. Cutaneous manifestations of leukaemia are called leukaemia cutis, and are regarded as a sign of poorer prognosis and shorter survival time. A single-institution retrospective review was performed of medical records of patients diagnosed with leukaemia cutis in the dermatology department of Seoul St Mary’s Hospital between January 2012 and April 2021. Fifty-six cases with cutaneous leukaemic involvement and underlying haematological malignancy were included (40 acute myelogenous leukaemia, 8 acute lymphoblastic leukaemia, 3 chronic myeloid leukaemia, 2 chronic lymphocytic leukaemia, and 3 myelodysplastic syndrome). Male-female ratio 1.9:1, mean age at diagnosis 45.8 years. Plaques (28%) and papules (27%) were the most common skin lesions, followed by patches (18%) and nodules (16%). Mean time from diagnosis of leukaemia to development of leukaemia cutis was 12.3 months. Forty-six patients (84%) died during the 7-year follow-up; mean time from diagnosis of leukaemia cutis to death was 5.4 months. The results suggest that leukaemia cutis is associated with poor outcomes in patients with leukaemia. Comprehensive skin examination of these patients may help diagnose leukaemia cutis early, enabling prompt treatment.

【 授权许可】

Unknown