Challenges in Discovering Drugs That Target the Protein–Protein Interactions of Disordered Proteins

International Journal of Molecular Sciences

Judit Oláh¹  Tibor Szénási¹  Attila Lehotzky¹  Judit Ovádi¹  Victor Norris² 

[1] Institute of Enzymology, Research Centre for Natural Sciences, ELKH, 1117 Budapest, Hungary;Laboratory of Microbiology Signals and Microenvironment, University of Rouen, 76821 Mont Saint Aignan, France;

关键词: protein–protein interaction;    drug target;    disordered proteins;    neurodegeneration;   

DOI  :  10.3390/ijms23031550

来源: DOAJ

【 摘 要 】

Protein–protein interactions (PPIs) outnumber proteins and are crucial to many fundamental processes; in consequence, PPIs are associated with several pathological conditions including neurodegeneration and modulating them by drugs constitutes a potentially major class of therapy. Classically, however, the discovery of small molecules for use as drugs entails targeting individual proteins rather than targeting PPIs. This is largely because discovering small molecules to modulate PPIs has been seen as extremely challenging. Here, we review the difficulties and limitations of strategies to discover drugs that target PPIs directly or indirectly, taking as examples the disordered proteins involved in neurodegenerative diseases.

【 授权许可】

Unknown