Adsorption of Bisphenol A to a Carbon Nanotube Reduced Its Endocrine Disrupting Effect in Mice Male Offspring

International Journal of Molecular Sciences

Wenwei Wang¹  Ledong Zhu¹  Chengke Zhang¹  Nana Liang¹  Xuejiao Liu¹  Shumei Zhai¹  Jianbo Jia¹  Cuijuan Jiang¹  Bin Zhang¹ 

[1] Key Laboratory of Colloid and Interface Chemistry, Ministry of Education,School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China;

关键词: carbon nanotubes (CNTs);    Bisphenol A (BPA);    contaminants adsorption;    environmental endocrine disrupting effect;    reproductive toxicity;   

DOI  :  10.3390/ijms150915981

来源: DOAJ

【 摘 要 】

Soluble carbon nanotubes (CNTs) have shown promise as materials for adsorption of environmental contaminants such as Bisphenol A (BPA), due to the high adsorption capacity and strong desorption hysteresis of BPA on CNTs. The adsorption of BPA to CNTs may change the properties of both BPA and CNTs, and induce different toxicity to human and living systems from that of BPA and CNTs alone. Herein, we report that oral exposure of BPA/MWCNT–COOH (carboxylated multi-walled carbon nantubes) adduct to mice during gestation and lactation period decreased the male offspring reproductive toxicity compared with those induced by BPA alone. The adduct decreased malondialdehyde (MDA) level in testis and follicle-stimulating hormone (FSH) in serum, but increased the level of serum testosterone in male offspring in comparison to BPA alone. Our investigations broadened the knowledge of nanotoxicity and provided important information on the safe application of CNTs.

【 授权许可】

Unknown